hrp0095p2-84 | Diabetes and Insulin | ESPE2022

Assessment of serum concetrations of decorin, vaspin and kallistatin in children with type 1 diabetes

Polkowska Agnieszka , Bossowski Filip , Żelazowska-Rutkowska Beata , Marcinkiewicz Katarzyna , Nesterowicz Miłosz , Leoniuk Rafał , Bossowski Artur

The increasing knowledge on the functions of gastric peptides and adipokines in the body allows the assumption of their major role linking the process of food intake, nutritional status, and body growth, largely through the regulation of glucose metabolism and insulin resistance. The aim of the study was the assessment of serum levels of selected gastric peptides and adipocytokines in children with type 1 diabetes, with respect to the disease duration. The study included 88 ch...

hrp0097rfc5.3 | Diabetes and insulin 1 | ESPE2023

3 Screen ICA ELISA–A new tool to identify pre-clinical diabetes in first-degree relatives of patients with type 1 diabetes (pre-d1abetes study)

Bossowski Artur , Noiszewska Klaudyna , Polkowska Agnieszka , Zasim Aneta , Jamiolkowska Milena , Mysliwiec Malgorzata , Szadkowska Agnieszka , Mazur Artur , Jarosz-Chobot Przemyslawa , Szypowska Agnieszka , Chobot Agata , Nazim Joanna , Zubkiewicz Agnieszka , Ben-Skowronek Iwona , Niechcial Elzbieta , Walczak Mieczyslaw , Jozwa Anita , Mincewicz-Wysocka Marta , Robak-Kotna Katarzyna , Chen Shu , Furmaniak Jadwiga , Smith Bernard

Introduction: Overt clinical symptoms of type 1 diabetes (T1D) are often preceded by a pre-clinical stage of varying duration. Diagnosis of the pre-clinical stage is difficult and is based on the presence of specific islet autoantibodies in the subject's blood. Objectives: Apparently healthy first-degree relatives of patients with T1D were tested using the 3 Screen ICAELISA (RSR Ltd) for combined testing for autoantibodies to GAD65 (glutamic acid decarbox...

hrp0095p1-241 | Diabetes and Insulin | ESPE2022

3 Screen ICA TM Elisa - A New Tool for Identify Pre-Clinical Diabetes in First-Degree Relatives of Patients with Type 1 Diabetes (Pre-D1Abetes Study)

Noiszewska Klaudyna , Bossowski Artur , Zasim Aneta , Jamiołkowska-Sztabkowska Milena , Polkowska Agnieszka , Mazur Artur , Brzuszek Marta , Fichna Piotr , Niechciał Elżbieta , Szalecki Mieczysław , Wysocka-Mincewicz Marta , Myśliwiec Małgorzata , Żalińska Magdalena , Szmigierko-Kawko Małgorzata , Noczyńska Anna , Zubkiewicz-Kucharska Agnieszka , Chobot Agata , Górska-Flak Karolina , Ochab Agnieszka , Szadkowska Agnieszka , Wyka Krystyna , Pietrzak Iwona , Pilecki Olgierd , Jarosz-Chobot Przemysława , Rusak Ewa , Beń-Skowronek Iwona , Sieniawska Joanna , Szypowska Agnieszka , Nazim Joanna , Walczak Mieczysław , Jóźwa Anita , Marcinkiewicz Katarzyna , Powell Michael , Amoroso Marie , Rees Smith Bernard , Furmaniak Jadwiga

Background and Aims: A pre-clinical stage of type 1 diabetes (T1D) often precedes by many years the overt clinical symptoms. Diagnosis during this period is often difficult and is based on the presence of specific islet autoantibodies in the subject's blood. First-degree relatives of patients with T1D were tested using the 3 Screen ICA TM ELISA (RSR Ltd) for combined testing for autoantibodies to GAD65 (glutamic acid decarboxylase, 65kDa isoform), ZnT8 (z...